To achieve a low reference spur for an Integer-N frequency synthesizer, a new spur reducing technique was proposed. To reduce the size of periodic ripples on the VCO control voltage, the low pass filter, and the charge pump were added with a spur reduction system. By lowering the amplitude of the periodic ripple on the VCO control voltage, we managed to lower the reference spur. The introduced technique removes the necessity to decrease bandwidth and CVO gain reference spur suppressing. To demonstrate the effectiveness of the proposed structure, a 2. 06 – 2. 22 GHz frequency synthesizer was used and the 180-nm CMOS technology was used for post-layout simulation. The proposed frequency synthesizer represents the reference spur of-85. 84 dBc at 20 MHz offset and phase noise of-108dBc/Hz at 200 kHz offset frequency also it is locked after 2. 8us while occupied 0. 35 mm2 of the chip area.

Introduction: The expected values of hematologic and serum biochemical parameters in domestic animal species can be affected by breed, age, environment, and nutrition. Established breed-specific reference intervals (RI) are an important tool for monitoring the health of sheep. There is a lack of published data on biochemical RI for Sngsari sheep. Thus, the aims of this study were to establish RI for select of serum biochemical parameters for Sangsari sheep by Reference Value Advisor (RVA) method and provide information on the studied parameters for both sex of this breed in order to form a basis for clinical interpretation. Materials and Methods: Sixty healthy Sangsari sheep including 26 ewes and 34 rams (2– 4 years old) were chosen from the breeding station of Sangsari sheep among 150 sheep in Damghan, Semnan, Iran. The type of feeding, all the animals had free access to water and to good-quality alfalfa hay (90. 0 % DM, 15. 8 CP % DM, 50. 4NDF%DM, 31. 6ADF%DM, 5. 8 lignin% DM, and 2. 2 EE % DM). Concentrate (23 % oats, 36 % corn, 38 % barley, and 3%mineral and vitamin supplements) was provided once daily (200 g per animal per day). In the sampling day, breeder signed a subscription form and completed a primary questionnaire consisting of specific questions about past and current health status, sexual status, medications used, and familial and reproductive medical history. Complete physical examinations were performed by the same experienced veterinarian on each sheep. In order to reduce stress, blood samples were taken in the station with minimal changes in the usual schedule of the sheep. Blood samples (taken from the jugular vein) were collected in simple tubes in order to separate the serum (centrifuged at 3000 rpm for 10 min) for biochemical analysis. Samples transported at +4 ° C to the laboratory department of the Faculty of Veterinary Medicine, Semnan, Iran. Biochemical parameters were measured by a autoanalyzer. These parameters included alkaline phosphatase (ALP), gamma glutamyletransferase (GGT), aspartate aminotransferase (AST), blood urea nitrogen (BUN), total protein (TP) and albumin (Alb). For statistical analysis, data were analyzed by Reference Value Advisor and outliers were deleted if detected according to Tukey or Dixon. RIs, according to sample size, were determined using a robust method and following Box-Cox transformation of data. The data were normally distributed, and differences between sexes in biochemical parameters were analyzed using independent sample T test. A value of P<0. 05 was considered as significant. Results and Discussion: The RI of biochemical parameters obtained from adult healthy Sangsari sheep includes the following: ALP 49. 24-564. 84 u/l; GGT 24. 14-62. 23 u/l; AST 10. 86-338. 40 u/l; BUN 6. 91-26. 43 mg/dl; TP 5. 19-13. 95 gr/dl and Alb 0. 92-3. 63 gr/dl. Established RI of biochemical parameters for ewes and rams, respectively including: ALP 29. 98-702. 89 u/l; GGT 22. 41-54. 49 u/l; AST 1. 36-279. 89 u/l; BUN 5. 9526. 86 mg/dl; TP 5. 75-12. 83 gr/dl; Alb 0. 84-2. 77 gr/dl and ALP 106. 08-568. 55 u/l; GGT 20. 80-58. 30 u/l; AST 360. 12 u/l; BUN 8. 15-26. 04 mg/dl; TP 4. 66-15. 59 g/dl and Alb 0. 74-3. 77 g/dl. Interpretation of the biochemical results in different breeds of sheep, with regard to RI for each parameter, in conjunction with history, clinical findings and other paraclinical tests helps the clinician to reach a definitive diagnosis. A unique feature of Sangsari sheep is that they are highly adaptable with desert and mountain ranges with high tolerance of drought conditions. This breed is also relatively small size and light weight, and most studies have focused on genetic characteristics associated with this trait. In view of the characteristics mentioned above and considering the lack of reference range for biochemical parameters, it is necessary to determine reference intervals in Sangsari sheep. In order to establish a comprehensive reference interval in Sangsari sheep, a select biochemical parameters were evaluated in the present study. Almost most of the established RI for biochemical parameters in this study differed from previously published RI, so that the lower and upper limits of RI of theses parameters (with the exception of BUN) were lower and higher than the values previously reported. Differences between obtained RI for the Sangsari sheep and previously reported RI for other breeds may be attributed to variations in hormonal influences, hydration status, dietary differences, or adaptations to a desert environment, age, breed, season of study and analytic method. Conclusion: The obtained data provided reference interval for biochemical parameters in Sangsari sheep for the first time. Present study demonstrates significant differences in most of the biochemical parameters. Reference intervals determined in this study provide a baseline for interpreting biochemical results in Sangsari sheep, and contribute to optimization of the management of this species.

Background & Objective: In addition to pyramidal neurons and interneurons, the hippocampus contains Astrocytes that play important roles in regulating ion flux currents, energy production, neurotransmitter release and memory. Learning needs some instrument for information storage and information maintenances mechanisms resemble to memory. The aim of this study was determination of spatial memory effect on the number of astrocytes in rat’s hippocampus.Materials & Methods: In this experimental study, with usage of Morris Water Maze and Reference memory technique, we used 10 male albino wistar rats. 5 rats were in control group and 5 rats in Reference memory group. After histological preparation, the slides were stained with PTAH staining for showing the Astrocytes. Results: The findings of this study showed significant difference in astrocytes number in CA1, CA2 and CA3 area of hippocampus between control and reference memory group. The mean and SD of astrocytes in CA1, CA2 and CA3 of reference memory group were 118.57±25.29, 58.91±23.59 and 116.6±31.14, that they are more than control group with 49±17.29 in CA1, 48.8±25.21 in CA2 and 41.95±11.22 in CA3. Conclusion: We concluded that the number of astrocytes increased due to spatial learning (e.g. reference memory method).

One of the common methods of river improvement and bank protection is using spur dikes. Building spur dikes makes the flow path to be modified. Concentrating the flow in the middle part of the river causes the river side not to be washed out. The new flow path makes the river bed next to the end of the spur dikes to be washed out. Usually the spur dikes are built in group because of extending the protected zone. The stability of these spur dikes against the river flow depends on stability of the first spur dike. The purpose of this laboratory research is to investigate different ways for reduction of erosion in the first spur dike. It is suggested to use a shorter (minor) spur dike at the upstream part perpendicular to the flow direction. Aim in this research , it is intended to find the optimum distance between shorter spur dike and first spur dike in order to have minimum erosion in the first spur dike. From the hydraulics point of view, L’/L (the length of shorter spur dike to the length of first spur dike ), X/L (the distance between first spur dike and shorter spur dike to the length of first spur dike) and Froude number has been studied and results has been presented in the form of equations.

Erosion is one of the most worrisome issues associated with the river and coastal sides. The use of spur dikes is one of the newest methods for controlling and reducing erosion. The spur dikes are in various forms, such as simple, l-shaped and t-shaped. In this experimental study, the effect of different geometry of upstream and downstream spur dikes on the scouring of middle t-shaped spur dike was study for a series of spur dike combinations. Experiments have been analyzed for movable bed in the threshold of motion condition. The results of this study showed that the average scour depth around the mid-t-shaped spur dike is about 0. 8 times the flow depth. The best performance of the t-shaped spur dike occurs when the upstream spur dike is l-shaped and downstream is t-shaped (L T T). In fact, the lowest volume and average scour depth due to the all situations is related to this combination. The erosion volume was calculated using the Surfer software. The average scouring volume of this combination is 0. 063 m3 and the average scour depth is about 1. 21 times the flow depth. At the site of the first spur dike, the entire amount of erosion on the side of spur dikes but by crossing the spur dikes, erosion is directed toward the opposite.

Spur dikes are river training structures that developed from the natural river banks with proper length and angle from the flow dominant direction, cause to divert the flow attack at the riverside and the critical regions and directs the flow to the river central axis. There are several researchers focused on the effect of the spur dikes angles on the flow pattern however there is not any study on hockey spur dikes angle on scouring patterns. In present study, the effects of the hockey spur dikes angle on scouring and the bed topography was carried out experimentally while the results were compared to those provided for L-shape. The experiments were conducted on a series of hockey spur dikes also the L-shape in three various angles equal to ,  and  (towards the downstream channel lateral walls) inside a laboratory flume in 10.5m length, 0.5 width and 0.5m height under the clear water conditions. The results revealed the scour hole parameters including the length and thickness of the sediment hill are lower in hockey spur dikes than the L- shape by increasing the spur dikes angle. Furthermore, the maximum scour depth, mean area and volume of scouring are increased by 41.4, 41 and 75.5 percent in hockey and by 33.8, 39 and 73 percent in L-shape through increasing the angle from   to , respectively. Also, no scouring was taken place in the vicinity of the channel lateral walls downstream the hockey spur dikes, hence, those beter act against the destruction also in protection of river beaches against the erosion, with respect to the L-shape.

Heel spur is a common medical condition that can cause substantial discomfort and reduce the quality of life of the affected patients. When seeking treatment for a heel spur, it is important to consider the differential diagnoses and underlying medical conditions that may contribute to the symptoms. This manuscript aims to explore several distinctive diagnostic possibilities, essential factors to consider, and practical strategies for managing heel spurs. This paper explains the common differential diagnoses and addresses medical conditions related to heel spurs. The importance of accurate diagnosis in planning treatment protocol is highlighted. In addition, we explain treatment strategies, including preventive measures, conservative treatments, and more advanced procedures. Physicians can help relieve pain and improve the quality of life of the affected individuals by considering the diverse aspects of managing heel spurs.

Entrapment of median nerve can be developed at multiple sites along this nerve. One of the compression sites of median nerve is supracondylar area of humerous. Sometimes struther ligament or spur or both of them are the rare cause of entrapment syndrome of the median nerve. Struther ligament or spur can compress ulnar nerve and/or brachial artery. These cases may have median ulnar nerve or brachial artery symptoms and they are sometimes asymptomatic which can accidentally be detected by radiography. Most commonly, these cases refer with median nerve compression syndrome and they complain about numbness and pain in their upper extremity. Sometimes pain radiates to shoulder and neck in the upper part and to hand in the lower part, that is mistakenly diagnosed as a sign of radiculopathy or other compression neuropathies. The present study is a case report of a 25-year-old man who referred with having pain and numbness in right upper extremity.

Spur dikes are hydraulic structures, which are built across the river from river bank towards centerline in order to protect the river bank from erosion, natural development of amending the river side, special protection of local structures, navigation and environmental rehabilitation of river. The main job of these structures is to divert the flow away from the bank and towards centerline of river. However, the velocity will increase and the complicate vortex will be formed around the spur nose and the protection of spur dikes against scouring and their stability is very important. Using riprap is the most common and economical method for spur dike protection. In this study the effect of relative height and length of the submerged spur dikes on riprap stability is investigated. The experiments were carried out in a laboratory flume with 90o bend and R/B=4.0. Six sizes of ripraps including 5.5, 7.9, 11.1, 14.3, 17.9, and 22.2 mm, with three relative spur length (15%, 20% and 25% of the flume width) and four dischrge (25, 29, 32 and 36 lit/s) were used. The results showed that the larger riprap failed for the higher relative spur height. With increasing the relative spur length the riprap stability decreased.Finally an experimental equation was developed based on the relative spur height and length and riprap size, which can be applied for designing of riprap size.